Effects of Ilex paraguariensis A. St.-Hil. (Yerba Mate) and Chlorogenic Acid on Creatine Phosphokinase, Lactate and Irisin Levels in Mice after Detraining



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Submitted Sep 13, 2022
Published Jan 24, 2023
10.24018/ejbio.2023.4.1.419

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This is the first report that deals with the effect of yerba mate (YM) and chlorogenic acid (CGA) consumption on blood total creatine phosphokinase (CPK), lactate and irisin levels after a detraining period. Healthy mice (n = 50) were randomly separated into the following experimental groups: SED = sedentary control; TRAIN = mice submitted to training (swimming) for 8 weeks; DETRAIN = mice submitted to training for four weeks and after submitted to detraining for four weeks; DETRAIN CGA = mice submitted to training for four weeks and after submitted to both detraining and standard CGA consumption for four weeks; DETRAIN YM = mice submitted to training for four weeks and after submitted to both detraining and consumption of roasted YM infusion for four weeks. No significant (p > 0.05) difference was found in relation to the lactate value. The DETRAIN CGA group had a lower CPK data when compared with the other groups. The DETRAIN YM group showed a lactate value slightly lower than that from DETRAIN CGA one. Blood irisin value had no statistical (p > 0.05) difference between studied groups. Irisin value in sedentary group had a value non-statistically (p > 0.05) significant when compared with the other groups after a detraining period. Therefore, CGA could decrease the protein catabolism via CPK inhibition during detraining. YM may maintain a part of the lipid mobilization during detraining, leading to the sparing of a fraction of the lactate.

Keywords: CPK, detraining, lactate, irisin, mice, Ylex paraguariensis

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